Product Description: AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].
Applications: COVID-19-immunoregulation
Formula: C10H5N3O3
References: [1]Cuzzocrea S, et al. The tyrosine kinase inhibitor tyrphostin AG126 reduces the development of acute and chronic inflammation. Am J Pathol. 2000 Jul;157(1):145-58./[2]Garg TK, et al. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003 Mar 21;3:5./[3]Dugo L, et al. The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Intensive Care Med. 2002 Jun;28(6):775-88./[4]Bullard LE, et al. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1722-31.
CAS Number: 118409-62-4
Molecular Weight: 215.17
Compound Purity: 98.0
Research Area: Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic;warming)
Target: ERK
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