Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (SP-4-3)-dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide-?N2,?S]-copper
Purity: ≥95%
Formula Markup: C11H9Cl2CuN3O2S
Formula Weight: 381.7
CAS Number: 902779-59-3
Notes: The kinase Akt (also known as protein kinase B or PKB) modulates cell proliferation, metabolism, and survival, as well as angiogenesis.{15560,16917} Akt inhibitor XI is a cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 µM).{30190} It also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells.{30190} Molecular modeling indicates that this inhibitor interacts with the pleckstrin homology and kinase domains of Akt. Akt inhibitor XI is commonly used in the range of 1-20 µM to assess the role of Akt in cellular responses.{30191,30192,30193}
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