Target: Alpha2C Adrenergic
Conjugate: HRP
Product Type: Monoclonal
Clone Number: N330A/80 (Formerly sold as S330A-80)
Immunogen: Synthetic peptide amino acids 442- 462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor
Swiss-Prot: P18825
Purification: Protein G Purified
Storage Buffer: 73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide and 0.23mM Citrate in dH2O
Concentration: 1 mg/ml
Specificity: Detects 50kDa or larger (possibly due to dimerization). Does not cross-react with other adrenergic receptors.
Cellular Localization: Cell Membrane
Scientific Background: The alpha 2C Adrenergic Receptor controls the release of neurotransmitter from central adrenergic neurons and from sympathetic nerves in the heart. This receptor also plays a role in cognitive and behavioral function. Two variants are produced by alternative splicing. Alpha 2C Adrenergic Receptor has been reported extensively in the brain. Blood, corpus cavermosum, kidney, and heart tissues have also been reported to express the protein.
References: 1. Filipeanu C.M., et al. (2011) Biochim Biophys Acta. 1813: 346-357.2. Powe D.G., et al. (2011) Breast Cancer Res Treat. 130: 457-463.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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