Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid
Purity: ≥98%
Formula Markup: C15H14O6
Formula Weight: 290.26806
CAS Number: 31186-12-6
Notes: Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.{47219,47220} It inhibits Src kinase with an IC50 value of 20 nM.{47221} Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM.{47219} It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day.{47220} Altenusin also has antioxidant and antifungal properties.
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