Alvelestat, CAS 848141-11-7

Product Description: Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC50 value of 7.9 nM, a Ki value of 9.4 nM and a Kd value of 9.5 nM[1].

Applications: COVID-19-immunoregulation

Formula: C25H22F3N5O4S

References: [1]Stevens T, et al. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther. 2011 Oct;339(1):313-20./[2]Li H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS. Oncotarget. 2017 Nov 28;9(2):1772-1784.

CAS Number: 848141-11-7

Molecular Weight: 545.53

Compound Purity: 99.87

Research Area: Inflammation/Immunology

Solubility: DMSO : ≥ 33 mg/mL

Target: Elastase

• SKU: MEXHY-15651-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15651-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK