Product Description: AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1].
Applications: Cancer-programmed cell death
Formula: C32H28F3N5O4
References: [1]Johnson M, et al. Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3339-43./[2]Walser TC, et al. Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 2006 Aug 1;66(15):7701-7./[3]Cambien B, et al. Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism. Br J Cancer. 2009 Jun 2;100(11):1755-64.
CAS Number: 473719-41-4
Molecular Weight: 603.59
Compound Purity: 99.65
Research Area: Cancer; Inflammation/Immunology; Endocrinology
Solubility: DMSO : ≥ 41 mg/mL
Target: CXCR
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