Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[(4-methoxyphenyl)methyl]-3-acetate-(2R,3S,4S)-3,4-pyrrolidinediol
Purity: ≥98%
Formula Markup: C14H19NO4
Formula Weight: 265.3
CAS Number: 22862-76-6
Notes: Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis.{20427} It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell proliferation in skin-transplanted mice.{20426} Through a caspase-8-dependent pathway, anisomycin acts as a potent and specific anoikis sensitizer of malignant epithelial cells resistant to apoptosis upon detachment from the ECM, preventing distal tumor formation in a mouse model of prostate cancer metastases.{20428}
English
Deutsch
