Antalarmin, CAS 157284-96-3

Product Description: Antalarmin is a selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1) antagonist with a Ki of 2.7 nM. Antalarmin can pass through the blood–brain barrier[1][2][3].

Applications: Neuroscience-Neurodegeneration

Formula: C24H34N4

References: [1]Ducottet C, et al. Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Jun;27(4):625-31./[2]Dong H, et al. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology (Berl). 2014 Dec;231(24):4711-22./[3]Zorrilla EP, et al. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Res. 2002 Oct 18;952(2):200-10.

CAS Number: 157284-96-3

Molecular Weight: 378.55

Compound Purity: 99.95

Research Area: Neurological Disease

Solubility: DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)

Target: CRFR

• SKU: MEXHY-124475-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124475-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK