CloneID: CET-M8
Antigen Long Description: 4-(2-carboxyethylthio)-11-deoxycortisol linked to bovine serum albumin.
Origin Pub PMID: 1922102
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: Binds specifically to 11-deoxycortisol. No cross-reactivity with cortisol or cortisone.
Application Notes (Clone): The antibody binds specifically to 11-Deoxycortisol, a glucocorticoid steroid hormone which can be oxygenated to cortisol. The monoclonal antibody recognises the functional groups at C-11 and C-21 in the steroid portion of 11-deoxycortisol, and can be useful in determining plasma levels of deoxycortisol in the metyrapone test in the diagnosis of Cushing's syndrome and adrenal insufficiency.
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