CloneID: 0325-6-9
Antigen Long Description: The original antibody was generated by immunizing mice with human alpha-fetoprotein.
Buffer Composition: PBS only.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Uniprot Accession No.: P02771
Specificity Statement: This antibody binds human alpha-fetoprotein (AFP). AFP is made in the liver of developing babies. It binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. AFP levels in healthy adults is very low. Elevated levels of AFP in adult human blood is a marker for cancer.
Application Notes (Clone): The specificity of this antibody towards hepatoma cells was determined using ELISA. The tumor targeting ability of the antibody was characterized using cell immunostaining and complement killings assays (PMID: 1379974).
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