CloneID: NAC32
Antigen Long Description: Biotin-labeled peptide spanning amino acids 53-87 of alpha-synuclein.
Origin Pub PMID: 18237741
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original human yeast surface display scFv format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P37840
Specificity Statement: Binds the nonamyloid component of alpha-Synuclein.
Application Notes (Clone): This is a synthetic IgG binding to alpha-Synuclein which is involved in the regulation of dopamine release and transport. It induces fibrillisation of the tau-protein and reduces the neuronal responsiveness to several apoptotic signals. Involved in the pathogenesis of Parkinson disease.
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