Anti-Angiogenin (26-2F)

Anti-Angiogenin [26-2F], Recombinant, IgG1 kappa, Mouse
SKU
ABAAb00400-1.4
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: 26-2F

Heavy Chain modification: Fc Silent™

Antigen Long Description: Human angiogenin.

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P03950

Specificity Statement: Binds to human angiogenin with a Kd of 1.6 nM. Minimal epitope is W89 and fragment 38-41 (PCKD).

Application Notes (Clone): The antibody binds specifically to angiogenin, a member of of the ribonuclease superfamily of proteins, which interacts with actin on the surface of endothelial and smooth muscle cells, inducing neovascularization. Due to its angiogenic activity, angiogenesis plays a key role in the growth and invasiveness of tumour cells, and therefore neutralising monoclonal antibodies such as 26-2F are important anticancer drugs. The monoclonal antibody 26-2F is not directly cytotoxic to tumour cells in vitro, however has been shown to have antagonistic effects in human breast cancer xenografts in athymic mice.
More Information
SKU ABAAb00400-1.4
Manufacturer Absolute Antibody
Manufacturer SKU Ab00400-1.4
Package Unit 200 μg
Quantity Unit STK
Reactivity Human, Rabbit
Clonality Recombinant
Application ELISA, Immunohistochemistry, Immunocytochemistry
Isotype IgG1 kappa
Host Mouse
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