CloneID: AbD1556
Antigen Long Description: Biotinylated BMPR-IA immobilized on a resin.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P36894
Specificity Statement: The antibody binds to human BMPR-IA with a low nanomolar affinity.
Application Notes (Clone): This antibody binds to human BMPR-1A, which, on ligand bindingg, forms a receptor complex acting as a serine/threonine kinase, activating SMAD transcriptional regulators. They positively regulate chondrocyte differentiation, for example. The antibody neutralizes BMP-binding to the receptor.
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