Anti-CCR2 antibody(DMC447); IgG1 Chimeric mAb

Background: The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1; a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3.

Description: Anti-CCR2 antibody(DMC447); IgG1 Chimeric mAb

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Formulation & Reconstitution: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Target: CCR2

Uniprot ID: P41597

Usage: Research use only

Clone ID: DMC447

Purification: Purified from cell culture supernatant by affinity chromatography

Recommended Dilutions: Flow Cyt 1:100

• SKU: DMADMC100447-500
• Manufacturer: DIMA Biotechnology
• Manufacturer SKU: DMC100447-500
• Package Unit: 500 µg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Flow Cytometry
• Isotype: Rabbit/Human Fc chimeric IgG1
• Host: Rabbit
• Conjugate: Unconjugated