CloneID: OX-40
Antigen Long Description: OX40 antibody was prepared by immunizing mice with phytohaemagglutinin-activated rat lymph node cells.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P15725
Specificity Statement: OX-40 antibody binds specifically to CD4+ T blasts. CD134 is a protein of the TNFR superfamily. It binds to OX40 ligand of both the monomeric and trimeric states which results in co-stimulated proliferation.
Application Notes (Clone): OX-40 antibody results in Fc-dependent (i.e. not Fab or F(ab')2) stimulation of in vitro activated T cell proliferation, but is not mitogenic for resting cells. This antibody can also label CD4+ T blasts and can pull down CD134/CD134+ cells.
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