CloneID: OX-110
Heavy Chain modification: Fc Silent™
Antigen Long Description: OX-110 was generated from rats using immunogenic mouse fusion protein mCD200RCD4d34.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q9ES57
Specificity Statement: OX-110 binds specifically to CD200R proteins. CD200R is a type I membrane protein and an inhibitory receptor for the CD200/OX-2 cell surface glycoportein. CD200R acts to limit inflammation by inhibiting expression of pro-inflammatory molecules such as TNF-alpha, interferons and iNOS in response to selected stimuli. CD200R is expressed on rodent myeloid cells and is involved in regulation of macrophage function.
Application Notes (Clone): OX-110 can be used to stain in FC.
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