CloneID: ZHB-2cF9
Antigen Long Description: The original antibody was obtained from a human single-chain antibody phage display library by solid-phase affinity screening of CD26 extracellular region protein.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P27487
Specificity Statement: The antibody is specific for the extracellular domain of CD26. CD26 is a cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
Application Notes (Clone): The specificity of the antibody was confirmed by ELISA analysis. The original format of the antibody could specifically bind to the CD26 extracellular domain protein. The antibody could detect CD26 expressed on the surface of human mesothelioma cells NCI-H2452 by immunofluorescence analysis. The antibody was able to inhibit the binding of human mesothelioma cell NCI-H2452 expressing CD26 to ECM. Further, the antibody could inhibit the proliferation of mesothelioma cells and colon cancer cells with high expression of CD26 (WO2015089881A1).
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