CloneID: OX-35
Heavy Chain modification: Fc Silent™
Antigen Long Description: OX-35 was prepared by immunizing mice with T blasts prepared inmixed lymphocyte reactions with purified rat T helper cells against irradiated spleen.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P05540
Specificity Statement: OX-35 shows specificity towards rat CD4 antigen. W3/25 and OX-36 bind to different epitopes on CD4 antigen. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction and is involved in regulation of T-cell activation.
Application Notes (Clone): This antibody is able to label cells expressing CD4 on their surface and can precipitate CD4 from detergent extracts of radioactively labelled thymocytes.
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