Anti-CD4 (OX-68)

Anti-CD4 [OX-68], Recombinant, IgG2a kappa, Mouse
SKU
ABAAb00587-2.3
Packaging Unit
200 μg
Manufacturer
Absolute Antibody

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CloneID: OX-68

Heavy Chain modification: Fc Silent™

Antigen Long Description: This antibody was prepared by subcutaneously injecting BALB/c mice with a soluble form of rat CD4, consisting of domains 3 and 4. A boost of a mixture of free sCD4 and sCD4 bound to cells was administered intravenously.

Buffer Composition: PBS with 0.02% Proclin 300.

Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7

Uniprot Accession No.: P05540

Specificity Statement: This antibody is reactive with rat CD4 domain 3 & 4, and is partly competitive with OX-67 & 69.

Application Notes (Clone): This antibody binds to rat CD4. Upon challenge with HIV-1, this antibody was able to significantly inhibit viral entry into HeLa cells expressing a mutant of rat CD4 that binds gp120 (SImon, 1997). Similarly, pre-binding of gp120 resulted in a 50% reduction in binding of this antibody, indicating epitope masking. Analogous effects on viral entry and synctium formation are observed with MAbs against human CD4.
More Information
SKU ABAAb00587-2.3
Manufacturer Absolute Antibody
Manufacturer SKU Ab00587-2.3
Package Unit 200 μg
Quantity Unit STK
Reactivity Rat (Rattus)
Clonality Recombinant
Application Immunoprecipitation, Western Blotting, Flow Cytometry, Surface Plasmon Resonance (SPR)
Isotype IgG2a kappa
Host Mouse
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