Anti-CD4 (OX-68)

Anti-CD4 [OX-68], Recombinant, IgG2b kappa, Rat
SKU
ABAAb00587-8.4-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

Availability: loading...
Price is loading...
CloneID: OX-68

Heavy Chain modification: Fc Silent™

Antigen Long Description: This antibody was prepared by subcutaneously injecting BALB/c mice with a soluble form of rat CD4, consisting of domains 3 and 4. A boost of a mixture of free sCD4 and sCD4 bound to cells was administered intravenously.

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: P05540

Specificity Statement: This antibody is reactive with rat CD4 domain 3 & 4, and is partly competitive with OX-67 & 69.

Application Notes (Clone): This antibody binds to rat CD4. Upon challenge with HIV-1, this antibody was able to significantly inhibit viral entry into HeLa cells expressing a mutant of rat CD4 that binds gp120 (SImon, 1997). Similarly, pre-binding of gp120 resulted in a 50% reduction in binding of this antibody, indicating epitope masking. Analogous effects on viral entry and synctium formation are observed with MAbs against human CD4.
More Information
SKU ABAAb00587-8.4-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab00587-8.4-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Rat (Rattus)
Clonality Recombinant
Application Immunoprecipitation, Western Blotting, Flow Cytometry, Surface Plasmon Resonance (SPR)
Isotype IgG2b kappa
Host Rat
Product information (PDF) Download
MSDS (PDF) Download