CloneID: 064-003
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was isolated by panning a phage display library against CD44.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P16070
Specificity Statement: The antibody is specific for CD44. CD44 is a transmembrane protein belonging to a hyaladherin family. It is a hyaluronic acid receptor. The CD44 molecule is expressed in almost all the cells and tissues. However, in general, it is not expressed in the platelet, liver cell, cardiac muscle, uridiferous tubule epithelium, testis, and skin.
Application Notes (Clone): The IgG1 format of the antibody specifically bound to the cancer cells expressing CD-44 (PC-14) and expresses the ADCC activity (US9388249B2).
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