CloneID: K53
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was isolated from a semi-synthetic phage library by panning against human CD46 expressed on the surface of B cells.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG3 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P15529
Specificity Statement: The antibody is specific for CD46.
Application Notes (Clone): The binding affinity of the original format of the antibody to CD46 was measured by surface plasmon resonance (Kd= 9.1×10^7 M). The antibody could bind to LS174T cells, as determined by FACS (US10934571B2).
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