CloneID: OX-101
Antigen Long Description: OX-101 was prepared by immunizing BALB/c mice with biotinylated rat thymocytes - this antibody was selected from a number of antibodies raised by the immunogen.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P97829
Specificity Statement: OX-101 binds specifically to CD47 and has been shown to compete with OX-41 for binding . CD47 acts as an adhesionn receptor for THBS1 on platelets and is involved in the modulation of integrins (signalling). Acts as a SIRPA receptor - SIRPA binding prevents maturation of immature dentritic cells and and inhibits cytokine production by mature dendritic cells. Possibly involved in changes to membrane permeability due to virus infection.
Application Notes (Clone): This antibody can be used for affinity chromatography purification and can block the interaction between OX41-CD4d3+4 beads and cells. In addition OX-101 can be used for FC and WB.
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