CloneID: 3H4
Antigen Long Description: The original antibody was generated by immunizing BALB/c mice with recombinant human CD70-mFc fusion protein as immunogen.
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P32970
Specificity Statement: This antibody binds human and cynomolgus monkey CD70, a cytokine belonging to the tumor necrosis factor (TNF) ligand family, which acts as a ligand for TNFRSF27/CD27. It is a surface antigen present on activated T and B cells. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. CD70 is also identified as an emerging target in cancer immunotherapy.
Application Notes (Clone): The binding this antibody to recombinant human CD70 was determined using ELISA. This antibody can positively react with human and cynomolgus monkey CD70 expressed on the surface of 786-0 renal carcinoma cells and CHO-K1-cmCD70 cells in a flow cytometric assay (CN110724670).
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