Anti-CNPS (3E5)

Anti-CNPS [3E5], Recombinant, IgG1 kappa, Human
SKU
ABAAb00354-10.0-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

Availability: loading...
Price is loading...
CloneID: 3E5

Antigen Long Description: A covalent serotype A Glucuronoxylomannan (GXM) -tetanus toxoid conjugate (GXM-TT).

Origin Pub PMID: 23911417

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original mouse IgG3 format for improved compatibility with existing reagents, assays and techniques.

Specificity Statement: Specifically binds to CNPS.

Application Notes (Clone): This antibody binds to Glucuronoxylomannan (GXM), which is the main constituent of the C. neoformans capsule and modulates the inflammatory response of monocytes. In a later study conducted by Yuan et al. 1998 (PMID: 9488395), it was shown that switching the original murine IgG3 antibody to other IgG subtypes, in particular IgG2A, significantly prolonged animal survival in an infection model.
More Information
SKU ABAAb00354-10.0-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab00354-10.0-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Various species
Clonality Recombinant
Application ELISA
Isotype IgG1 kappa
Host Human
Product information (PDF) Download
MSDS (PDF) Download