CloneID: AFA
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing mice with α2Ct.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgA format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P02452
Specificity Statement: The antibody is specific for the C-terminal telopeptide region of human collagen I.
Application Notes (Clone): The original antibody could block the binding activity of the C-terminal telopeptide region of human collagen I. Biosensor assays of binding interactions of the original format and the Fab fragment of the antibody with procollagen I and the α2Ct were measured (Kd = 663pM for the original antibody and 268nM for the Fab fragment and 21pM for the original antibody and 57nM for the Fab fragment for procollagen and α2Ct respectively) (US20200048333A1).
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