CloneID: 11.2.1
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by panning against a human library.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG2 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P16410
Specificity Statement: The original antibody is specific for CTLA-4.
Application Notes (Clone): The antibody was used in combination with CpG ODN PF3512676 for treatment of breast cancer in vivo.