CloneID: C3B6
Antigen Long Description: The original antibody was generated by hyperimmunizing mice with UV irradiated polydeoxynucleotides.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody recognizes UV-irradiated polynucleotides and oligonucleotides that contain the (6–4)-dipyrimidine photoproduct.
Application Notes (Clone): This antibody is recommended for detection of DNA damage caused by UV irradiation. This antibody is also known as αUVssDNA-1. Recombinant C3B6 scFv binds UV-poly(dT) in an ELISA with no evidence of cross-reactivity with unirradiated polythymidylic acid [poly(dT)](PMID: 10710441).
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