CloneID: RD301
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing a mouse with a cytoskeletal extract of Chicken gizzard.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG2b format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P17661
Specificity Statement: The antibody is specific for desmin. Desmin is a 53 kDa intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle).
Application Notes (Clone): The antibody detected desmin in western blot analysis. The original antibody showed staining pattern of desmin in BHK cells (Quax et al., 1985; PMID: 3855248). The antibody stained desmin on smooth muscle cells of rat prostatic tissue by indirect immunofluorescence (Verhagen et al., 1988; PMID: 2458583).
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