CloneID: PIA174
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was raised by isolating it from a B cell culture supernatant.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human Fab format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: A0A059QA82
Specificity Statement: This antibody is specific for DIII domain of fusion glycoprotein F0 from human respirovirus 3.
Application Notes (Clone): The original antibody was used for an ELISA on parainfluenza virus type 3. Further the structure of this antibody was determined using cryo-EM (Stewart-Jones et al., 2018;PMID:30420505). This antibody was used for a plaque reduction assay on Vero cells infected with parental or escape variant of human respirovirus. This antibody was used for a neutralization assay. It showed here that it disrupted the formation of the HN/F complex (Marcink et al., 2023; PMID:36763666). This antibody was used for surface plasmon resonance on LuS-N71-SpyLinked-PIV3 F (Zhang et al., 2020; PMID:33097791).
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