CloneID: Fab-1791
Heavy Chain modification: Fc Silent™
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: O75084
Specificity Statement: The antibody is specific for FZD7. The antibody recognises human FZD7, but not with mouse FZD7.
Application Notes (Clone): The antibody detected the recombinant human FZD7 by western blot analysis. The antibody reduced FZD7 signaling in breast cancer cell line MDA- B-231 about 3-fold. This antibody was used for detection of FZD7 expressed on OVCAR4 cells by flow cytometry. The antibody could block migration of a breast cancer cell line and ovarian cancer cell line OVCAR4. This antibody was used for immunohistochemistry on ovarian carcinoma and renal cell carcinoma samples (WO2016205566A1).
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