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Application: Useful for binding assays and avidin-pulldown assays.
Assay Conditions: The assay was performed according to GITR:GITRL TR-FRET Assay Kit (#79054).
Background: GITR (Glucocorticoid-Induced TNFR-Related protein), also known as TNFRSF18 (tumor necrosis factor receptor superfamily member18) or CD357 (Cluster of Differentiation 357), is a co-stimulatory receptor belonging to the TNF (tumor necrosis factor) receptor superfamily. It is constitutively expressed on regulatory T cells (Tregs) and is upregulated on activated CD4+ and CD8+ T cells, NK (natural killer) cells, and myeloid cells. GITR interacts with its ligand, GITRL, to modulate immune responses by enhancing effector T cell activation and proliferation while reducing Treg-mediated suppression. Due to its dual role in promoting immune activation and attenuating immune regulation, GITR is a promising target for cancer immunotherapy and autoimmune disease research.
Description: Recombinant anti-GITR antibody recognizing human GITR (Glucocorticoid-Induced TNFR-Related protein) protein. This anti-GITR antibody is a purified, human recombinant monoclonal antibody, which contains an Avi-Tag™ and is biotinylated at the C-terminus of the heavy chain unit. This antibody has been tested in a binding assay.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host Cell Line: HEK293
Purity: ≥85%
Storage Stability: At least 12 months at -80°C.
Tags: This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation confirmed to be ≥90%.
Target: GITR
Uniprot: Q9Y5U5
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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