Anti-Glucose-dependent insulinotropic Receptor (Gipg013)

Anti-Glucose-dependent insulinotropic Receptor [Gipg013], Recombinant, IgG lambda, Rabbit

CloneID: Gipg013

Antigen Long Description: Human GIPr.

Buffer Composition: PBS only.

Chimeric Use Statement: This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Uniprot Accession No.: Q8TDV5

Specificity Statement: The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.

Application Notes (Clone): This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81%.

• SKU: ABAAb00424-23.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab00424-23.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Dog (Canine)
• Clonality: Recombinant
• Application: Immunofluorescence, ELISA, Blocking
• Isotype: IgG lambda
• Host: Rabbit