CloneID: SL5
Antigen Long Description: A single chain fragment variable (scFv) phage display library was constructed from a simian immunodeficiency virus (SIV)-infected rhesus macaque. The original antibody was isolated by panning onto oligomeric (gp140) and monomeric (gp120) forms of SIV Env glycoprotein.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This full-length chimeric rabbit antibody was made using the variable domain sequences of the original scFv format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: B0LB91
Specificity Statement: The antibody is specific for gp41.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The scFv format was able to neutralize SIVmac316. The original antibody was converted in the scFv-Fc format and its specificity validated by WB (Ita et al., 2017; PMID: 28075174).
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