CloneID: 2E9
Antigen Long Description: The original antibody was generated from the peripheral blood lymphocytes of glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT)-immunized individual.
Origin Pub PMID: 7622223
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: This antibody is specific for GXM or glucuronoxylomannan from Cryptococcus neoformans. GXM is a polysaccharide expressed on the surface of C. neoformans. This antibody binds an epitope of C. neoformans that is different from the epitope of another anti-GXM antibody 2H1.
Application Notes (Clone): This antibody was used for the immunofluorescent labelling of C. neoformans serotype D and A. This antibody can be used in combination with another anti-GXM antibody 2H1 for detection of all four serotypes of C. neoformans GXM using sandwich ELISA. The antibody 2H1 is used as capture antibody and 2E9 is used as a detection antibody (PMID: 7622223).
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