Antigen Long Description: The original antibody was generated from the peripheral blood lymphocytes of glucuronoxylomannan-tetanus toxoid conjugate (GXM-TT)-immunized individual.
Origin Pub PMID: 7622223
Buffer Composition: PBS only.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgM format for improved compatibility with existing reagents assays and techniques.
Specificity Statement: This antibody is specific for GXM or glucuronoxylomannan from Cryptococcus neoformans. GXM is a polysaccharide expressed on the surface of c.neoformans.
Application Notes (Clone): This antibody can be used in combination with another anti-GXM antibody 2H1 for detection of all four serotypes of C. neoformans GXM using sandwich ELISA. The antibody 2H1 is used as capture antibody and 2E9 is used as a detection antibody (PMID: 7622223).