CloneID: 5D2
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was generated by immunizing 2 NOD/SCID mice with the monoclonal antibody TMβ1, PBMC from a human donor and E1s.
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Uniprot Accession No.: P27958
Specificity Statement: The antibody is specific for envelope protein 1 of Hepatitis C virus. The antibody recognizes an epitope in E1 represented by aa region 313-326.
Application Notes (Clone): The specificity of the Fab format of the antibody was confirmed by ELISA analysis. Further, the antibody was able to neutralize genotype 2a, 1a and 4a of HCV. The affinity of the antibody was measured using peptide IGP 2254 (ITGHRMAWDMMMNWS). Association and dissociation of this peptide to the immobilized antibody was measured using SPR (Kd= 0.06 nM) (US20090104207).
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