Anti-HCV IRES junction IIIabc (HCV2)

Anti-HCV IRES junction IIIabc [HCV2], Recombinant, IgG1 kappa, Human
SKU
ABAAb02951-10.0-BT
Packaging Unit
1 mg
Manufacturer
Absolute Antibody

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CloneID: HCV2

Antigen Long Description: The original antibody was generated by panning against HCV IRES construct.

Buffer Composition: PBS only.

Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human Fab format for improved compatibility with existing reagents assays and techniques.

Specificity Statement: The antibody recognizes a region located around the four-way junction structure – JIIIabc. In particular, the antibody interacts with the four unpaired nucleotides (A162, G163, U164 and A165) from the IIIa loop and an unpaired nucleotide (G233) and three base-paired nucleotides (G231, C232 and C237) from IIIc.

Application Notes (Clone): Specificity of this antibody was confirmed by ELISA tests. The antibody binds the RNA with dissociation constants of 32 ± 7 nM specifically recognizing the so-called junction IIIabc (JIIIabc). In vitro translation assay demonstrated that the antibody binds to junction IIIabc of HCV IRES inhibiting IRES-mediated translation in a concentration-dependent manner, which indicates this antibody might be used in the development of the therapeutic agents (PMID: 31765566)
More Information
SKU ABAAb02951-10.0-BT
Manufacturer Absolute Antibody
Manufacturer SKU Ab02951-10.0-BT
Package Unit 1 mg
Quantity Unit STK
Reactivity Virus
Clonality Recombinant
Application ELISA
Isotype IgG1 kappa
Host Human
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