CloneID: UL-5 A1
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P01903; P04439
Specificity Statement: This antibody recognizes a conformational epitope formed by the HLA-DR1 and the HLA-A2 peptide 'SDWRFLRGYHQYA' and binds to pMHC-II in a similar fashion as T cells.
Application Notes (Clone): The specificity of this antibody to recognize peptide/MHC complex epitope on HLA-A2+, -DR1/DRB1*0101+ typed lymphoblast cell lines was tested using flow cytometry. This antibody can also recognize HLA-A2-,-DR1/DRB1*0101+ LCLs exogenously loaded with HLA-A2 peptides (105-117, 103-117) (PMID: 9805656).
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