CloneID: iVHH4
Antigen Long Description: The original antibody was generated by immunizing a llama with N-terminal htt protein, followed by phage-VHH display library construction. The antibody was isolated by biopanning against wild-type or mutant N-terminal htt fragment.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a chimeric antibody, developed from the original camelid VHH antibody, specifically engineered for enhanced compatibility with existing reagents, assays, and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P42858
Specificity Statement: The antibody is specific for wild-type and mutant human huntingtin under native and denatured conditions. The antibody epitope is located between amino acids 49–148.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The antibody detected the htt by western blot analysis. The antibody could co-immunoprecipitate htt from human HD brain lysates (Schut et al., 2015; PMID: 25294428).
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