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Applications: Useful for binding studies and for the inhibition of IL-17RA:IL-17A interactions.
Assay Conditions: Antibody was added atvarious concentrations using the IL-17RA[Biotin]:IL-17A Inhibitor Screeningbinding assay (BPS Cat. #72060). Assay wasperformed according to the recommendedprotocol.
Description: Neutralizing recombinant humanchimeric antibody recognizing human IL-17A.This antibody has not been tested for crossreactivitywith other species.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Purification: Purified using protein A affinitychromatography from HEK293 supernatants.
Storage Stability: Stable for at least 12 months at-80°C.
Uniprot: Q16552
Warnings: Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 - 0.5%) at 4°C, stable for 2 weeks.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lubberts, E., et al., Arthritis Rheum. 2004; 50(2): 650-659.
2. Cheng, X., et al., Atherosclerosis. 2011; 215(2): 471-474.
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