CloneID: IAD7
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original antibody was selected from existing phage display libraries.
Origin Pub PMID: 17539823
Buffer Composition: PBS only.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for keratin with an increased affinity for native keratin over sulfur mustard-exposed (SM-exposed) keratin.
Application Notes (Clone): The binding characteristics of this antibody were observed in an ELISA and immunoslotblot (ISB) assay. Increased exposure levels of keratin resulted in a decreased emission, indicating decreased stability of the antibody-keratin interactio; the formation of adducts or crosslinks disrupts effective antibody binding (Bikker et al., 2007; PMID: 17539823).
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