Anti-LAG-3 (Ab8438)

Anti-LAG-3 [Ab8438], Recombinant, IgG1 kappa, Human

CloneID: Ab8438

Buffer Composition: PBS only.

Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG4 format for improved compatibility with existing reagents assays and techniques.

Uniprot Accession No.: P18628

Specificity Statement: The antibody is specific for human LAG-3. The antibody cross-reacts with cynomolgus LAG-3. The antibody does not cross react with murine LAG-3.

Application Notes (Clone): The antibody is a humanized version of the mouse antibody mab84c. The humanized antibody could bind to hLAG-3+ cells, with an EC50 value that does not exceed 1.5nM. The humanized antibody prevented the binding activity of human LAG-3 and Daudi cells. The binding affinity of the humanized antibody was measured by surface plasmon resonance (Kd= 0.71 nM). The antibody was employed to design bispecific antibodies against LAG-3 and PD-L1, which antibody retained the binding activity to dual-target LAG3 and PD-1. Further, both the combination of the antibody and PD-1 antibody and the bispecific LAG-3 and PD-L1 antibody showed a good tumour inhibition effect in in vivo application (CN111848794).

• SKU: ABAAb03510-10.0-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03510-10.0-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Recombinant
• Application: Surface Plasmon Resonance (SPR), In Vivo Assay
• Isotype: IgG1 kappa
• Host: Human