CloneID: 133A2
Antigen Long Description: The original antibody was generated by immunizing a BALB/c mouse with partially purified recombinant human lamin A.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P02545
Specificity Statement: The antibody recognizes an epitope located between residues 598-611 of lamin A.
Application Notes (Clone): The antibody detected lamin A by western blot analysis (Hozák et al., 1995; PMID: 7769007 and Broers et al., 1997; PMID: 9243284). The original format of the antibody strongly stained all tubular epithelium cells of kidney by immunohistochemistry (Broers et al., 1997; PMID: 9243284). The original antibody was used for staining of Sertoli cells, Leydig cells and Peritubular cells in normal testis and parenchyma adjacent to TGCT by immunohistochemistry (Machiels et al., 1997; PMID: 9274531). This antibody was used for detection of lamin A expressed on CHO-K1 cells by flow cytometry (Broers et al., 1999; PMID: 10504295). The original antibody was used to stain lamin A on late apoptotic cell (Broers et al., 2002; PMID: 12553668). The antibody detected laimin A in fibroblast cells by immunofluorescence analysis (van Tienen et al., 2019; PMID: 30420677).
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