CloneID: 1-12
Antigen Long Description: The original antibody was originated by immunizing rabbits with an LgR5 extracellular domain (ECD) huFc.
Buffer Composition: PBS only.
Uniprot Accession No.: O75473
Specificity Statement: The antibody is specific for human LgR5. The antibody binds an epitope outside the region of amino acids 22 to 322 of human LgR5.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The original format of the antibody could recognise human LgR5 expressed in 293 cells by FACS. The original format of the antibody was used to detect expression of LgR5 on normal human tissues by immunohistochemistry. The antibody stained normal intestinal crypts in the expected pattern. The antibody also showed moderate staining in hair follicle, and weak staining in fallopian tube, endometrium, adrenal gland, and spinal cord. Further, the antibody detected LgR5 in different colon cancer cell lines (SW403, SW948, CACO-2, T84, KM-12, C2BBel, SW1463, SK-CO-1, LOVO) by immunohistochemistry (US20190248889).
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