CloneID: 252
Heavy Chain modification: Fc Silent™
Antigen Long Description: The original format of the antibody was generated by immunizing transgenic mice with human M-CSF.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: P09603
Specificity Statement: The antibody is specific for M-CSF.
Application Notes (Clone): The original format of the antibody inhibited mouse monocytic cell proliferation in response to M-CSF. Further, the IC50 for inhibition of mouse nonocytic cell proliferation was determined for the antibody (IC50 = 86.7 nM). The binding properties of the original format of the antibody were analyzed using SPR analysis (Kd= 0.13 pM) (US7326414B2).
English
Deutsch
