CloneID: 5H4
Buffer Composition: PBS only.
Uniprot Accession No.: P09603
Specificity Statement: The antibody is specific for M-CSF. The antibody binds to a linear epitope represented by ITFEFVDQE, amino acids 65-73 of M-CSF.
Application Notes (Clone): The binding properties of the original format of the antibody were analyzed using SPR analyses (Kd = 3 nM). The antibody could neutralize human M-CSF activity, as measured by a proliferation assay with M-NFS-60 cell line. Further, the Fab fragment of the antibody was able to neutralize human M-CSF activity, but with less potency. The humanized variant of the antibody was constructed (EP1913028B1).