CloneID: ham150-3.5
Antigen Long Description: The original antibody was generated from a hamster immunized with mouse BCL-3.
Buffer Composition: PBS with 0.02% Proclin 300.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Hamster IgG format for improved compatibility with existing reagents assays and techniques.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Uniprot Accession No.: Q9Z2F6
Specificity Statement: The antibody is specific for BCL-3. B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells.
Application Notes (Clone): The specificity of the original format of the antibody for mBcl-3 was confirmed by ELISA analysis. The antibody detected mBcl-3 and human Bcl-3 by western blot (Bassetti et al., 2009; PMID: 19208752).
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