Anti-NKp46 (NKP46-4)

Anti-NKp46 [NKP46-4], Recombinant, IgG1 kappa, Human

CloneID: NKP46-4

Heavy Chain modification: Fc Silent™

Antigen Long Description: The original antibody was isolated using phage display technology after three rounds of panning against human NKp-46.

Buffer Composition: PBS only.

Chimeric Use Statement: This full-length reformatted human antibody was made using the variable domain sequences of the original Human scFv format for improved compatibility with existing reagents assays and techniques.

Uniprot Accession No.: O76036

Specificity Statement: The antibody is specific for human NKp46. The antibody cross-reacts with cynomolgus monkey and rhesus macaque NK46 but does not cross-react with mouse NKp46. NKp46 is a receptor expressed by NK cells.

Application Notes (Clone): The binding specificity of this antibody towards human, cynomolgus monkey and rhesus monkey NKp-46 was determined using ELISA and flow cytometry. The binding of this antibody to NKp-46 expressed on the surface of CHOK1 and NK cells was confirmed using flow cytometry. The original IgG antibody bound ectodomain of human NKp-46 with a binding affinity of Kd= 1.1 nM. This binding of this antibody to NK cells resulted in an increase in the interferon gamma release (CN113637074).

• SKU: ABAAb03381-10.3-BT
• Manufacturer: Absolute Antibody
• Manufacturer SKU: Ab03381-10.3-BT
• Package Unit: 1 mg
• Quantity Unit: STK
• Reactivity: Human, Primate, Cynomolgus Monkey (Primate)
• Clonality: Recombinant
• Application: ELISA, Flow Cytometry
• Isotype: IgG1 kappa
• Host: Human