CloneID: 12B10
Antigen Long Description: A phage-displayed antibody library was generated from peripheral blood of healthy persons. The original antibody was isolated by screened using purified virus-like particles (VLPs) of strain Narita 104 (r104, genogroup II, genotype 4).
Buffer Composition: PBS with 0.02% Proclin 300.
Available Custom Conjugation Options: AP, HRP, Fluorescein, APC, PE, Biotin Type A, Biotin Type B, Streptavidin, FluoroProbes 647H, Atto488, APC/Cy7, PE/Cy7
Specificity Statement: The antibody is specific for Norovirus GII.4. It shows intra-genogroup cross-reactivity to genotypes 1, 4, 6, and 7 of genogroup II.
Application Notes (Clone): The specificity of the original format of the antibody was confirmed by ELISA analysis. The blocking activity of the antibody against the interaction of homotypic VLPs with histo-blood group antigens were also assessed as an alternative to neutralization assay. The antibody prevented the binding of r104 to histo-blood group antigens that had been reported to bind r104.
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